Abstract |
Arsenic plays an important role in producing oxidative stress in cultured cells. To investigate the interaction between high oxidative stress and low arsenic methylation capacity on arsenic carcinogenesis, a case-control study was conducted to evaluate the relationship among the indices of oxidative stress, such as urinary 8-hydroxydeoxyquanine (8-OHdG), as well as plasma micronutrients and urinary arsenic profiles on urothelial carcinoma (UC) risk. Urinary 8-OHdG was measured using high-sensitivity enzyme-linked immunosorbent assay kits. The urinary arsenic species were analyzed using high-performance liquid chromatography and hydride generator-atomic absorption spectrometry. Plasma micronutrient levels were analyzed using reversed-phase high-performance liquid chromatography. The present study showed a significant protective effect of plasma alpha-tocopherol on UC risk. Plasma alpha-tocopherol levels were significantly inversely related to urinary total arsenic concentrations and inorganic arsenic percentage ( InAs%), and significantly positively related to dimethylarsinic acid percentage (DMA%). There were no correlations between plasma micronutrients and urinary 8-OHdG. Study participants with lower alpha-tocopherol and higher urinary total arsenic, higher InAs%, higher MMA%, and lower DMA% had a higher UC risk than those with higher alpha-tocopherol and lower urinary total arsenic, lower InAs%, lower MMA%, and higher DMA%. These results suggest that plasma alpha-tocopherol might modify the risk of inorganic arsenic-related UC.
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Authors | Chi-Jung Chung, Yeong-Shiau Pu, Ying-Ting Chen, Chien-Tien Su, Chia-Chang Wu, Horng-Sheng Shiue, Chao-Yuan Huang, Yu-Mei Hsueh |
Journal | The Science of the total environment
(Sci Total Environ)
Vol. 409
Issue 6
Pg. 1039-45
(Feb 15 2011)
ISSN: 1879-1026 [Electronic] Netherlands |
PMID | 21227482
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 Elsevier B.V. All rights reserved. |
Chemical References |
- Antioxidants
- Carcinogens, Environmental
- Guanine
- 8-oxo-7,8-dihydrodeoxyguanine
- 8-Hydroxy-2'-Deoxyguanosine
- alpha-Tocopherol
- Arsenic
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Topics |
- 8-Hydroxy-2'-Deoxyguanosine
(analogs & derivatives)
- Antioxidants
(metabolism)
- Arsenic
(metabolism, toxicity, urine)
- Carcinogens, Environmental
(metabolism, toxicity)
- Carcinoma
(epidemiology, metabolism, prevention & control)
- Case-Control Studies
- DNA Damage
- Female
- Guanine
(analogs & derivatives, metabolism, urine)
- Humans
- Linear Models
- Male
- Middle Aged
- Multivariate Analysis
- Oxidative Stress
(drug effects)
- Risk Factors
- Urologic Neoplasms
(epidemiology, metabolism, prevention & control)
- alpha-Tocopherol
(metabolism)
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