Associations between vaccination and childhood cancers in Texas regions.

Abstract

OBJECTIVES:

To determine whether children born in Texas regions with higher vaccination coverage had reduced risk of childhood cancer.

STUDY DESIGN:

The Texas Cancer Registry identified 2800 cases diagnosed from 1995 to 2006 who were (1) born in Texas and (2) diagnosed at ages 2 to 17 years. The state birth certificate data were used to identify 11 200 age- and sex-matched control subjects. A multilevel mixed-effects regression model compared vaccination rates among cases and control subjects at the public health region and county level.

RESULTS:

Children born in counties with higher hepatitis B vaccine coverage had lower odds of all cancers combined (OR = 0.81, 95% CI: 0.67 to 0.98) and acute lymphoblastic leukemia (ALL) specifically (OR = 0.63, 95% CI: 0.46 to 0.88). A decreased odds for ALL also was associated at the county level with higher rates of the inactivated poliovirus vaccine (OR = 0.67, 95% CI: 0.49 to 0.92) and 4-3-1-3-3 vaccination series (OR = 0.62, 95% CI: 0.44 to 0.87). Children born in public health regions with higher coverage levels of the Haemophilus influenzae type b-conjugate vaccine had lower odds of ALL (OR: 0.58; 95% CI: 0.42 to 0.82).

CONCLUSIONS:

Some common childhood vaccines appear to be protective against ALL at the population level.

• Authors: Melissa A Pagaoa, M Fatih Okcu, Melissa L Bondy, Michael E Scheurer
• Journal: The Journal of pediatrics (J Pediatr) Vol. 158 Issue 6 Pg. 996-1002 (Jun 2011) ISSN: 1097-6833 [Electronic] United States
• PMID: 21227448 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Mosby, Inc. All rights reserved.

Chemical References

• Haemophilus Vaccines
• Hepatitis B Vaccines
• Poliovirus Vaccines
• Vaccines

Topics

• Adolescent
• Case-Control Studies
• Child
• Child, Preschool
• Female
• Haemophilus Vaccines (therapeutic use)
• Hepatitis B Vaccines (therapeutic use)
• Humans
• Infant
• Male
• Medical Oncology (methods)
• Neoplasms (epidemiology, prevention & control)
• Odds Ratio
• Pediatrics (methods)
• Poliovirus Vaccines (therapeutic use)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (prevention & control)
• Regression Analysis
• Texas
• Vaccines (adverse effects)