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The luteinizing hormone-releasing hormone pulse generator in men: abnormalities and clinical management.

Abstract
Most men with hypogonadotropic eunuchoidism have absent luteinizing hormone and presumably absent luteinizing hormone-releasing hormone pulses. Pulsatile luteinizing hormone-releasing hormone therapy is effective in restoring normal gonadotropin secretion and testicular function and inducing fertility in men with hypogonadotropic eunuchoidism. Furthermore, pulsatile (versus continuous) luteinizing hormone-releasing stimulation of the pituitary gland is an absolute requirement for normal gonadotropin secretion. Men with idiopathic oligoazoospermia and selective elevation of follicle-stimulating hormone levels have slow luteinizing hormone and presumably luteinizing hormone-releasing pulse frequency. In these men, pulsatile luteinizing hormone--releasing treatment is effective in decreasing serum follicle-stimulating hormone levels, but it is unclear whether spermatogenesis and fertility are improved.
AuthorsA M Matsumoto, K M Gross, C B Sheckter, W J Bremner
JournalAmerican journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 163 Issue 5 Pt 2 Pg. 1743-52 (Nov 1990) ISSN: 0002-9378 [Print] United States
PMID2122731 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Gonadotropin-Releasing Hormone
  • Testosterone
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
Topics
  • Eunuchism (drug therapy, physiopathology)
  • Female
  • Follicle Stimulating Hormone (blood, metabolism)
  • Gonadotropin-Releasing Hormone (administration & dosage, metabolism)
  • Humans
  • Infertility, Male (etiology)
  • Luteinizing Hormone (blood, metabolism)
  • Male
  • Oligospermia (drug therapy, physiopathology)
  • Pregnancy
  • Radioimmunoassay
  • Testosterone (blood)

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