Abstract | BACKGROUND: Early diagnosis of acute coronary syndrome (ACS) is frequently a challenging task, while immediate risk stratification remains crucial for the prompt implementation of appropriate therapy in this setting. Employing markers that increase rapidly after the symptom onset may enhance triage and therapeutic decision-making in patients suspected for ACS. Myeloperoxidase (MPO) exerting proinflammatory and pro-oxidative properties is suggested as a reliable early marker for ACS associated with unfavourable clinical outcome. We assessed the diagnostic efficacy of plasma MPO alone or in combination with cardiac troponin I (cTnI) for detecting ACS in patients presenting with chest pain initiating within 6h before the hospital admission. MATERIAL AND METHODS: RESULTS: Both MPO and cTnI values were significantly lower in non-ACS subjects than in patients with ACS. At 97·5th percentile as cut-off, the superiority of MPO over cTnI was observed in patients with unstable angina and non-ACS subjects. Considerably higher MPO concentrations were demonstrated in the troponin-negative ACS patients on admission who became troponin-positive after 6h. Combined evaluation of MPO and cTnI possessed remarkably higher sensitivity than assessment of cTnI alone in all patients with ACS. CONCLUSIONS:
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Authors | Marcin Sawicki, Grazyna Sypniewska, Marek Kozinski, Marzenna Gruszka, Magdalena Krintus, Karolina Obonska, Marta Pilaczynska-Cemel, Jacek Kubica |
Journal | European journal of clinical investigation
(Eur J Clin Invest)
Vol. 41
Issue 6
Pg. 667-71
(Jun 2011)
ISSN: 1365-2362 [Electronic] England |
PMID | 21226709
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2011 The Authors. European Journal of Clinical Investigation © 2011 Stichting European Society for Clinical Investigation Journal Foundation. |
Chemical References |
- Biomarkers
- Troponin I
- Peroxidase
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Topics |
- Acute Coronary Syndrome
(diagnosis)
- Adult
- Aged
- Area Under Curve
- Biomarkers
(blood)
- Case-Control Studies
- Chest Pain
(etiology)
- Female
- Humans
- Male
- Middle Aged
- Peroxidase
(blood)
- Predictive Value of Tests
- Risk Assessment
- Time Factors
- Troponin I
(blood)
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