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Resolution of hepatopulmonary syndrome after methadone withdrawal as demonstrated by right to left shunt study.

Abstract
We present the right to left shunt study findings of a 50-year-old male patient with hepatitis C cirrhosis, who complained of worsening dyspnea on exertion. Follow-up images showed resolution of hepatopulmonary syndrome following methadone withdrawal although there had been no improvement in his liver disease. This was unusual and may have been due to the effect of opiate receptors on nitric oxide signaling in the pulmonary vasculature.
AuthorsBjoern Kitzing, Paul J Torzillo, Kevin C Allman
JournalClinical nuclear medicine (Clin Nucl Med) Vol. 36 Issue 2 Pg. 152-3 (Feb 2011) ISSN: 1536-0229 [Electronic] United States
PMID21220987 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Methadone
Topics
  • Anastomosis, Surgical
  • Hepatopulmonary Syndrome (diagnostic imaging, pathology, physiopathology, surgery)
  • Humans
  • Liver Cirrhosis (drug therapy)
  • Male
  • Methadone (therapeutic use)
  • Middle Aged
  • Radionuclide Imaging
  • Withholding Treatment

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