[Newly developed stenocardia: effect of diet with increased amount of polyunsaturated fatty acids of the omega-3 group on blood lipids and apolipoproteins].

Abstract

The effects of omega-3 polyunsaturated fatty acids (PUSF), a 4-week fish diet--350 g of scomber a day, on the blood lipid-apolipoprotein spectrum were evaluated in 22 patients with primary angina pectoris as compared to 8 control subjects received hospital protein-, fat-, carbohydrate-, and calorie-balanced diet No. 10 differing in omega-3 PUSF content (5 and 0.03 g/day, respectively). The fish diet caused a significant reduction in total cholesterol (TC) and low density lipoprotein cholesterol (LDLC) in patients with hypercholesterolemia, however, the normal cholesterol (under 200 mg/dl) and LDLC (under 130 mg/dl) levels were reached only in a small proportion of the patients. There was a hypotriglyceridemic effect of omega-3 PUSF that was more pronounced at initially high triglyceride concentrations. Heterogeneous changes were found in LDLC levels with the fish diet. i.e. from a great decrease at initially high LDLC levels to a small increase at initially low LDLC in patients with hypertriglyceridemia and low levels of high density lipoproteins. It was concluded that a fish diet should be included into a complex of measures aimed at the secondary prevention of coronary heart disease in patients with primary angina concurrent with hypercholesterolemia (even moderate) and hypertriglyceridemia unassociated with hypoalphacholesterolemia.

• Authors: O M Kalinkina, N A Gratsianskiĭ, N V Perova, V A Metel'skaia, V P Zykova, A M Olfer'ev, R G Oganov
• Journal: Kardiologiia (Kardiologiia) Vol. 30 Issue 7 Pg. 34-8 (Jul 1990) ISSN: 0022-9040 [Print] Russia (Federation)
• Vernacular Title: Vpervye voznikshaia stenokardiia: vliianie diety s povyshennym soderzhaniem polinenasyshchennykh zhirnykh kislot gruppy omega-3 na lipidy i apolipoproteiny krovi.
• PMID: 2122053 (Publication Type: English Abstract, Journal Article)

Chemical References

• Apolipoprotein A-I
• Apolipoproteins A
• Apolipoproteins B
• Fatty Acids, Omega-3
• Hypolipidemic Agents
• Lipids
• Triglycerides
• Cholesterol

Topics

• Adult
• Angina Pectoris (blood, diet therapy)
• Animals
• Apolipoprotein A-I
• Apolipoproteins A (blood)
• Apolipoproteins B (blood)
• Cholesterol (blood)
• Fatty Acids, Omega-3 (administration & dosage)
• Fishes
• Humans
• Hypolipidemic Agents
• Lipids (blood)
• Male
• Middle Aged
• Triglycerides (antagonists & inhibitors, blood)