[V89L polymorphism of the testosterone 5-alpha-reductase II gene and prognostic factors of prostate cancer].

Abstract

OBJECTIVE:

To investigate the association of V89L polymorphism of the SRD5A2 gene with the prognostic factors of prostate cancer (PCa).

METHODS:

We identified the V89L polymorphic sites of the SRD5A2 gene after Rsa-1 restriction enzyme digestion, observed the distribution of V89L (VV, VL and LL) polymorphism in 112 PCa and 89 benign prostate hyperplasia (BPH) patients, and determined the association of V89L polymorphism with the age, free PSA (fPSA), total PSA (tPSA), fPSA/tPSA ratio, tumor stage and Gleason score of the PCa patients.

RESULTS:

No statistically significant differences were found in the V89L polymorphism-induced genetic risk frequencies between the PCa and BPH groups (chi2 = 3. 606, df = 2, P = 0. 165), nor any significant correlation between the genotypes of VV and VL + LL and the differences in the fPSA, tPSA, fPSA/tPSA ratio, tumor stage, Gleason score and age of the PCa patients. VV and VL + LL showed no obvious association with the prognostic factors of PCa.

CONCLUSION:

V89L polymorphism is not related with the prognosis of PCa, but may be indirectly associated with its risk.

• Authors: Ming Tong, Yan-Yang Jin, Gang Li, Si-Ming Liu, Chun-Dong Ji
• Journal: Zhonghua nan ke xue = National journal of andrology (Zhonghua Nan Ke Xue) Vol. 16 Issue 11 Pg. 990-3 (Nov 2010) ISSN: 1009-3591 [Print] China
• PMID: 21218640 (Publication Type: English Abstract, Journal Article)

Chemical References

• Membrane Proteins
• 3-Oxo-5-alpha-Steroid 4-Dehydrogenase
• SRD5A2 protein, human

Topics

• 3-Oxo-5-alpha-Steroid 4-Dehydrogenase (genetics)
• Aged
• Aged, 80 and over
• Genotype
• Humans
• Male
• Membrane Proteins (genetics)
• Middle Aged
• Neoplasm Staging
• Polymorphism, Genetic
• Prognosis
• Prostatic Neoplasms (diagnosis, genetics, pathology)