Omeprazole pellets containing mucoadhesive
tablets were developed by direct punch method. Three mucoadhesive
polymers namely hydroxypropylemethylcellulose K4M,
sodium carboxy
methylcellulose, carbopol-934P and
ethyl cellulose were used for preparation of
tablets which intended for prolong action may be due to the attachment with intestinal mucosa for relief from active
duodenal ulcer. Mucoadhesive
tablets were coated with respective
polymer and coated with
Eudragit L100 to fabricate
enteric coated tablets. The prepared
tablets were evaluated for different physical parameters and dissolution study were performed in three dissolution mediums like 0.1N
hydrochloric acid for 2h, pH 6.5 and pH 7.8
phosphate buffer solution for 12hr.
Sodium carboxymethylcellulose showed above 95% release within 10 h where as carbopol-934P showed slow release about 88% to 92% over a period of 12 h. having excellent mucoadhesive strength but
ethyl cellulose containing
tablets showed less than 65% release. The release mechanism of all formulation was diffusion controlled confirmed from Higuchi's plot. Thus, the present study concluded that, carbopol-934P containing mucoadhesive
tablets of
omeprazole pellets can be used for local action in the
ulcer disease as well as for oral controlled release drug delivery.