Abstract | BACKGROUND: METHODS: NCTC 2472 tumor cells (2.5 × 10(5)) were injected into the femur of adult male C3H/HeJ mice to evoke bone tumor and bone cancer pain. To develop bone tumor, radiologic pictures were obtained. To assess pain, the withdrawal threshold was measured by applying a von Frey filament to the tumor cells inoculation site. The effect of intrathecal ginsenosides was investigated. Effect of ginsenosides (150, 500, 1,000 µg) was examined at 15, 30, 60, 90, 120 min after intrathecal delivery. RESULTS: The intrafemoral injection of NCTC 2472 tumor cells induced a radiological bone tumor. The withdrawal threshold with tumor development was significantly decreased compared to the sham animals. Intrathecal ginsenosides effectively increased the withdrawal threshold in the bone cancer site. CONCLUSIONS:
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Authors | Myung Ha Yoon, Woong Mo Kim, Hyung Gon Lee, Jeong Il Choi, Yeo Ok Kim, Ji A Song |
Journal | The Korean journal of pain
(Korean J Pain)
Vol. 23
Issue 4
Pg. 230-5
(Dec 2010)
ISSN: 2093-0569 [Electronic] Korea (South) |
PMID | 21217885
(Publication Type: Journal Article)
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