Transplanted olfactory ensheathing cells reduce the gliotic injury response of Müller cells in a rat model of retinitis pigmentosa.

Abstract

Retinitis pigmentosa leads to progressive visual loss and blindness. Until now there has been no effective therapy. Experimental studies have shown that transplantation of olfactory ensheathing cells into CNS lesions reorganizes the glial scar and stimulates axon regeneration. We now report that cultured syngeneic adult rat olfactory ensheathing cells transplanted into the subretinal space of pigmented Royal College of Surgeon rats survived for a minimum of 8weeks, migrated into surrounding space, and suppressed the gliotic injury response of the Müller cells. Further investigation of intraretinal transplantation of olfactory ensheathing cells may suggest a possible future route for protection of the retina in retinitis pigmentosa.

• Authors: Shu Jia Huo, Ying Li, Geoffrey Raisman, Zheng Qin Yin
• Journal: Brain research (Brain Res) Vol. 1382 Pg. 238-44 (Mar 25 2011) ISSN: 1872-6240 [Electronic] Netherlands
• PMID: 21215725 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier B.V. All rights reserved.

Topics

• Animals
• Brain Tissue Transplantation (methods)
• Cell Culture Techniques
• Cells, Cultured
• Disease Models, Animal
• Gliosis (pathology, prevention & control, therapy)
• Neuroglia (pathology, physiology, transplantation)
• Olfactory Mucosa (pathology, physiology, transplantation)
• Rats
• Rats, Transgenic
• Retina (pathology, physiopathology, surgery)
• Retinitis Pigmentosa (pathology, surgery)
• Treatment Outcome