The pharmacological activities of the
n -butanol alkaloids extracted from the stem bark of Hunteria zeylanica (Retz) Gardn. ex Thw. ( H. zeylanica ) and its major constituent,
strictosidinic acid, on nociceptive response using writhing and hot plate tests, the
antipyretic activity in yeast-induced
fever,
pentobarbital-induced sleep, and locomotor activity were examined in mice.
Oral administration of H. zeylanica extract at 200 mg/kg significantly decreased the number of contortions and stretchings induced by
acetic acid but not heat-induced
pain.
Strictosidinic acid (5-20 mg/kg, p.o.) also produced a similar effect but less pronounced than the extract. The
antipyretic effect of
strictosidinic acid (5-20 mg/kg, p.o.) was stronger than that of the extract (100-200 mg/kg, p.o.). The H. zeylanica extract dose-dependently (50-200 mg/kg, p.o.) prolonged the duration of pen-tobarbital-induced sleep but had no sign ificant effect on locomotor activity. No effect of
strictosidinic acid was noted on both
pentobarbital-induced sleep and locomotor activity. These results suggest that the H. zeylanica extract possesses peripheral
analgesic and mild
antipyretic effects and its major constituent,
strictosidinic acid, exerts a similar
analgesic effect with marked
antipyretic activity.