Abstract |
Leukemic cells of a 20 year old patient, suffering from acute lymphoblastic leukemia, were characterized by surface marker and functional analysis. A significant cell population within this type of leukemia expresses concomitantly the CD4 and CD8 antigen on the same cell and might represent a new differentiation stage of T-cells with the gamma/ delta receptor. The leukemic cells show a distinct pattern of growth response to mitogens and lymphokines, which might correlate to their differentiation stage. Moreover, a "natural killer"-like activity can be induced in these cells by IL-2.
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Authors | M Wilhelm, H P Tony |
Journal | Blut
(Blut)
Vol. 61
Issue 4
Pg. 213-8
(Oct 1990)
ISSN: 0006-5242 [Print] Germany |
PMID | 2121298
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, Differentiation, T-Lymphocyte
- Antigens, Surface
- CD4 Antigens
- CD8 Antigens
- Receptors, Antigen, T-Cell
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Topics |
- Adult
- Antigens, Differentiation, T-Lymphocyte
(analysis)
- Antigens, Surface
(analysis)
- CD4 Antigens
(analysis)
- CD8 Antigens
- Cytotoxicity Tests, Immunologic
- Humans
- Leukemia-Lymphoma, Adult T-Cell
(immunology, pathology)
- Male
- Receptors, Antigen, T-Cell
(physiology)
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