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Characterization of an acute T lymphoblastic leukemia expressing the gamma/delta T-cell receptor.

Abstract
Leukemic cells of a 20 year old patient, suffering from acute lymphoblastic leukemia, were characterized by surface marker and functional analysis. A significant cell population within this type of leukemia expresses concomitantly the CD4 and CD8 antigen on the same cell and might represent a new differentiation stage of T-cells with the gamma/delta receptor. The leukemic cells show a distinct pattern of growth response to mitogens and lymphokines, which might correlate to their differentiation stage. Moreover, a "natural killer"-like activity can be induced in these cells by IL-2.
AuthorsM Wilhelm, H P Tony
JournalBlut (Blut) Vol. 61 Issue 4 Pg. 213-8 (Oct 1990) ISSN: 0006-5242 [Print] Germany
PMID2121298 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Surface
  • CD4 Antigens
  • CD8 Antigens
  • Receptors, Antigen, T-Cell
Topics
  • Adult
  • Antigens, Differentiation, T-Lymphocyte (analysis)
  • Antigens, Surface (analysis)
  • CD4 Antigens (analysis)
  • CD8 Antigens
  • Cytotoxicity Tests, Immunologic
  • Humans
  • Leukemia-Lymphoma, Adult T-Cell (immunology, pathology)
  • Male
  • Receptors, Antigen, T-Cell (physiology)

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