Abstract | BACKGROUND: In the skin, eosinophils are found in a broad spectrum of diseases, including infectious diseases. OBJECTIVE: In this study, we investigated whether eosinophil extracellular traps, structures containing DNA in association with eosinophil granule proteins able to bind and kill bacteria, are present in the skin under various pathologic conditions. METHODS: RESULTS: CONCLUSION: Eosinophil extracellular traps are seen in both infectious and noninfectious inflammatory skin diseases and are particularly common in Wells syndrome.
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Authors | Dagmar Simon, Susanne Hoesli, Nina Roth, Simon Staedler, Shida Yousefi, Hans-Uwe Simon |
Journal | The Journal of allergy and clinical immunology
(J Allergy Clin Immunol)
Vol. 127
Issue 1
Pg. 194-9
(Jan 2011)
ISSN: 1097-6825 [Electronic] United States |
PMID | 21211654
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. |
Chemical References |
- Eosinophil Granule Proteins
- DNA
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Topics |
- DNA
(immunology, metabolism)
- Eosinophil Granule Proteins
(metabolism)
- Eosinophils
(immunology, metabolism)
- Extracellular Matrix
(immunology, metabolism)
- Fluorescent Antibody Technique
- Humans
- Microscopy, Confocal
- Skin Diseases
(immunology, metabolism)
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