Abstract | OBJECTIVE: To describe a novel technique of delivering mitomycin C safely via endoscopic sinus surgery. CASE REPORT:
Mitomycin C was applied in the median frontal drainage pathway of a 44-year-old woman suffering from recalcitrant chronic frontal sinusitis. The mitomycin C was soaked onto a neurosurgical patty, which was delivered through a nasopharyngeal tube trimmed to ensure delivery directly to the desired area, thus sparing adjacent mucosa. CONCLUSIONS:
Mitomycin C has been suggested to have a useful role in reducing post-operative scarring after endonasal surgery. The long term safety of topical mitomycin C is not yet known, and inadvertent topical application to adjacent mucosa should be avoided. The described technique achieves this in a simple manner, and can be easily applied to other locations.
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Authors | T Gutierrez, C Hopkins |
Journal | The Journal of laryngology and otology
(J Laryngol Otol)
Vol. 125
Issue 3
Pg. 309-10
(Mar 2011)
ISSN: 1748-5460 [Electronic] England |
PMID | 21211112
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antibiotics, Antineoplastic
- Mitomycin
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Topics |
- Administration, Topical
- Adult
- Antibiotics, Antineoplastic
(administration & dosage, pharmacology)
- Chronic Disease
- Cicatrix
(etiology, prevention & control)
- Drug Delivery Systems
- Endoscopy
(adverse effects)
- Female
- Frontal Sinusitis
(surgery)
- Humans
- Mitomycin
(administration & dosage, pharmacology)
- Nasal Cavity
- Recurrence
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