Abstract | OBJECTIVE: The primary aim of this study was to compare the in vivo efficacy and safety of dentifrices containing either 5% NovaMin or 5% potassium nitrate, and a non-desensitizing dentifrice, on dentin hypersensitivity in a four-week, double-blind clinical study among a population in south India. In addition, a companion scanning electron microscopy evaluation was performed to demonstrate whether or not the test products occlude open dentin tubules in vitro. METHODS: Thirty volunteers with tooth sensitivity were recruited, and a double-blind, randomized, parallel, controlled clinical trial was conducted in a hospital setting. Clinical evaluation for dentin hypersensitivity was done using tactile, air blast, and cold water methods. Following baseline measures, subjects were randomly divided into three groups and treated as follows: Group A-- dentifrice containing 5% potassium nitrate; Group B-- dentifrice containing 5% NovaMin; and Group C-- dentifrice containing no desensitizing ingredients. Clinical evaluations were repeated after two and four weeks of product use. RESULTS: CONCLUSION:
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Authors | Sowmya Salian, Srinath Thakur, Sudhindra Kulkarni, Guy LaTorre |
Journal | The Journal of clinical dentistry
(J Clin Dent)
Vol. 21
Issue 3
Pg. 82-7
( 2010)
ISSN: 0895-8831 [Print] United States |
PMID | 21207919
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dentifrices
- Dentin Desensitizing Agents
- Nitrates
- NovaMin
- Potassium Compounds
- Silicates
- potassium nitrate
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Topics |
- Adult
- Analysis of Variance
- Dentifrices
(pharmacology, therapeutic use)
- Dentin
(drug effects, ultrastructure)
- Dentin Desensitizing Agents
(pharmacology, therapeutic use)
- Dentin Permeability
- Dentin Sensitivity
(drug therapy)
- Double-Blind Method
- Female
- Glass
- Humans
- Male
- Middle Aged
- Nitrates
(therapeutic use)
- Pain Measurement
- Potassium Compounds
(therapeutic use)
- Silicates
(pharmacology, therapeutic use)
- Statistics, Nonparametric
- Young Adult
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