A clinical study of the effect of calcium sodium phosphosilicate on dentin hypersensitivity--proof of principle.

Abstract

OBJECTIVE:

NovaMin is technically described as amorphous sodium calcium phosphosilicate, and has been shown in laboratory studies to rapidly occlude dentin tubules through the deposition of particles that react to form a protective layer, similar to bone mineral, on the dentin surface. NovaMin was originally developed as a bone regenerative material and is highly biocompatible. The objective of this pilot study was to compare the safety and effectiveness of two prototype formulations containing 2.5% and 7.5% w/w NovaMin to a placebo dentifrice for the treatment of dentin hypersensitivity.

METHODS:

This was a randomized, double-blind, placebo-controlled pilot study. Sixty-six subjects with a confirmed diagnosis of dentin hypersensitivity were randomized to one of three treatments: 2.5% NovaMin, 7.5% NovaMin, or placebo. Two standard test stimuli, tactile and thermal air, were applied to sensitive cervical dentin surfaces. Subjects recorded the intensity of sensitivity in response to each stimulus on a visual analog scale at baseline, and after two, four, and eight weeks of twice-daily product use. Oral soft tissues were examined and spontaneous reports of adverse experiences were also monitored.

RESULTS:

Comparison of the mean change from baseline among the three treatment groups indicated a meaningful reduction in sensitivity scores in the 7.5% group that was significant compared to reductions observed in the placebo control group at all time points.

CONCLUSION:

The results of this study are supportive of the incorporation of NovaMin into products intended for the reduction of dentin hypersensitivity.

• Authors: Leonard Litkowski, David C Greenspan
• Journal: The Journal of clinical dentistry (J Clin Dent) Vol. 21 Issue 3 Pg. 77-81 ( 2010) ISSN: 0895-8831 [Print] United States
• PMID: 21207918 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Dentifrices
• Dentin Desensitizing Agents
• NovaMin
• Silicates

Topics

• Adult
• Analysis of Variance
• Dentifrices (administration & dosage, therapeutic use)
• Dentin Desensitizing Agents (administration & dosage, therapeutic use)
• Dentin Sensitivity (drug therapy)
• Double-Blind Method
• Female
• Glass
• Humans
• Male
• Pain Measurement
• Pilot Projects
• Safety
• Silicates (administration & dosage, therapeutic use)
• Statistics, Nonparametric