Immunopathology of postprimary tuberculosis: increased T-regulatory cells and DEC-205-positive foamy macrophages in cavitary lesions.

Abstract	Postprimary tuberculosis occurs in immunocompetent people infected with Mycobacterium tuberculosis. It is restricted to the lung and accounts for 80% of cases and nearly 100% of transmission. Little is known about the immunopathology of postprimary tuberculosis due to limited availability of specimens. Tissues from 30 autopsy cases of pulmonary tuberculosis were located. Sections of characteristic lesions of caseating granulomas, lipid pneumonia, and cavitary stages of postprimary disease were selected for immunohistochemical studies of macrophages, lymphocytes, endothelial cells, and mycobacterial antigens. A higher percentage of cells in lipid pneumonia (36.1%) and cavitary lesions (27.8%) were positive for the dendritic cell marker DEC-205, compared to granulomas (9.0%, P < .05). Cavities contained significantly more T-regulatory cells (14.8%) than found in lipid pneumonia (5.2%) or granulomas (4.8%). Distribution of the immune cell types may contribute to the inability of the immune system to eradicate tuberculosis.
Authors	Kerry J Welsh, Semyon A Risin, Jeffrey K Actor, Robert L Hunter
Journal	Clinical & developmental immunology (Clin Dev Immunol) Vol. 2011 Pg. 307631 ( 2011) ISSN: 1740-2530 [Electronic] Egypt
PMID	21197439 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
Chemical References	Antigens, Bacterial Antigens, CD Biomarkers DEC-205 receptor Lectins, C-Type Minor Histocompatibility Antigens Receptors, Cell Surface
Topics	Antigens, Bacterial (analysis, immunology) Antigens, CD (analysis, immunology) Autopsy Biomarkers (analysis) Dendritic Cells (immunology, pathology) Foam Cells (immunology, pathology) Granuloma (immunology, microbiology, pathology) Humans Immunohistochemistry Lectins, C-Type (analysis, immunology) Lung (immunology, microbiology, pathology) Minor Histocompatibility Antigens Mycobacterium tuberculosis (immunology) Organ Specificity Pneumonia, Lipid (immunology, microbiology, pathology) Receptors, Cell Surface (analysis, immunology) T-Lymphocytes, Regulatory (immunology, pathology) Tuberculosis, Pulmonary (immunology, microbiology, pathology)

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