Atopic dermatitis-like skin lesions reduced by topical application and intraperitoneal injection of Hirsutenone in NC/Nga mice.

Abstract	Atopic dermatitis (AD) is a common inflammatory skin disease. The increasing prevalence and severity of AD have prompted the developments of safer, more effective drugs. Although topical corticosteroids have been used as first line therapy for AD, their potential side effects limit their clinical applications. To investigate the effect of hirsutenone (HIR), a diarylheptanoid compound, on AD-like skin lesions and other factors related to immune response is the aim of this paper Th2-related cytokines (IL-4, IL-5, IL-13), eosinophil, IgE inflammatory factors (COX-2, iNOS) levels were reduced in blood, lymphocytes, and tissue after HIR treatment. These results suggest that HIR might be an effective treatment for AD.
Authors	Mi Sook Jeong, Sun Eun Choi, Ji Young Kim, Jung Shim Kim, Eun Joo Kim, Kwan Hee Park, Do Ik Lee, Seong Soo Joo, Chung Soo Lee, Hyoweon Bang, Mi-Kyung Lee, Young Wook Choi, Kap-sok Li, Nam Ju Moon, Min Won Lee, Seong Jun Seo
Journal	Clinical & developmental immunology (Clin Dev Immunol) Vol. 2010 Pg. 618517 ( 2010) ISSN: 1740-2530 [Electronic] Egypt
PMID	21197410 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Catechols Diarylheptanoids Interleukins hirsutenone oregonin Immunoglobulin E Nitric Oxide Synthase Type II Nos2 protein, mouse Ptgs2 protein, mouse Cyclooxygenase 2
Topics	Administration, Cutaneous Animals Catechols (administration & dosage, chemical synthesis, therapeutic use) Cyclooxygenase 2 (blood) Dermatitis, Atopic (drug therapy, pathology) Diarylheptanoids (administration & dosage, chemical synthesis, isolation & purification, therapeutic use) Disease Models, Animal Eosinophils (drug effects) Female Immunoglobulin E (blood) Injections, Intraperitoneal Interleukins (blood) Mice Mice, Inbred Strains Nitric Oxide Synthase Type II (blood) Skin (pathology)

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