Abstract | OBJECTIVE: STUDY DESIGN: We compared bupivacaine 0.5% and articaine 4% with an epinephrine concentration of 1:200 000 in a crossover design model of extraction of bilaterally symmetrical mandibular third molars. RESULTS: Regarding efficacy, patients experienced less postoperative pain at 6 and 12 hours and shorter duration of soft tissue anesthesia with articaine. With respect to safety, no differences were found between the anesthetics compared, showing a similar local and systemic toxicity. With regard to the preference of patients, it was higher for articaine, the main reasons being the greater postoperative pain and swelling with bupivacaine. CONCLUSION: It can be concluded that articaine seems to be a more appropriate anesthetic for the extraction of mandibular third molars due to the shorter duration of the anesthetic effect in the soft tissues, lower pain reported by patients during the immediate postoperative period and the personal preference of patients for this drug.
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Authors | Anna Trullenque-Eriksson, Blanca Guisado-Moya |
Journal | Medicina oral, patologia oral y cirugia bucal
(Med Oral Patol Oral Cir Bucal)
Vol. 16
Issue 3
Pg. e390-6
(May 01 2011)
ISSN: 1698-6946 [Electronic] Spain |
PMID | 21196829
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anesthetics, Local
- Carticaine
- Bupivacaine
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Topics |
- Anesthetics, Local
(therapeutic use)
- Bupivacaine
(therapeutic use)
- Carticaine
(therapeutic use)
- Cross-Over Studies
- Double-Blind Method
- Female
- Humans
- Male
- Mandible
- Molar, Third
(surgery)
- Tooth Extraction
- Young Adult
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