Abstract | BACKGROUND: OBJECTIVE: Encapsulation of pcDNA3.1+PA plasmid, encoding protective antigen (PA) of Bacillus anthracis (B. anthracis) into cationic liposomes, and evaluation of its effect on specific humoral specific immunity against PA were aimed. METHODS: CONCLUSION: A higher concentration of specific IgG against PA was found in sera of a group immunized with the encapsulated plasmid compared with the naked plasmid alone. This difference was significant for IgG1 isotype.
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Authors | Fatemeh Vahedi, Mohammad Reza Jaafari, Mahmoud Mahmoudi |
Journal | Iranian journal of immunology : IJI
(Iran J Immunol)
Vol. 7
Issue 4
Pg. 210-6
(Dec 2010)
ISSN: 1735-1383 [Print] Iran |
PMID | 21189443
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, Bacterial
- Bacterial Vaccines
- Cations
- Immunoglobulin G
- Liposomes
- Vaccines, DNA
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Topics |
- Animals
- Antigens, Bacterial
(administration & dosage, genetics, immunology)
- Bacillus anthracis
(genetics, immunology)
- Bacterial Vaccines
(genetics, immunology)
- Cations
- Female
- Gene Transfer Techniques
- Immunity, Humoral
(immunology)
- Immunization
- Immunoglobulin G
(blood)
- Liposomes
- Mice
- Mice, Inbred BALB C
- Plasmids
(genetics, immunology)
- Survival Analysis
- Vaccines, DNA
(administration & dosage, genetics, immunology)
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