Analysis of cytological changes in hepatocytes from rats dosed with 3'-methyl-4-dimethylaminoazobenzene: initial response appears to involve cytokinesis of binucleated cells.

Abstract

The reduction in the ratio of tetraploid (4N + 2 X 2N) to diploid (2N) hepatocytes in the adult rat after treatment with the hepatocarcinogen 3'-methyl-4-dimethylaminoazobenzene (3'M) has been investigated. Analysis of isolated hepatocytes 18-28 days after treatment has confirmed that initially some of the 2 X 2N hepatocytes are converted into 2N cells by cytokinesis, and that there is no DNA synthesis during this process. Shortly afterwards nonpolyploidizing growth commences by proliferation of some 2N cells.

• Authors: M D Kelly, J A Styles, N R Pritchard
• Journal: Cancer letters (Cancer Lett) Vol. 53 Issue 1 Pg. 1-4 (Aug 1990) ISSN: 0304-3835 [Print] Ireland
• PMID: 2118826 (Publication Type: Journal Article)

Chemical References

• Methyldimethylaminoazobenzene
• p-Dimethylaminoazobenzene

Topics

• Administration, Oral
• Animals
• Cell Cycle (drug effects)
• Cell Nucleus (drug effects, physiology)
• Interphase (drug effects)
• Liver (cytology, drug effects, ultrastructure)
• Male
• Methyldimethylaminoazobenzene (administration & dosage, pharmacology)
• Ploidies
• Rats
• p-Dimethylaminoazobenzene (pharmacology)