Abstract | BACKGROUND: MATERIALS AND METHODS: Eight-week-old mice with a strong predisposition to testicular or prostate cancer were gavaged with mifepristone. Olive oil was used in place of mifepristone in order to provide a control. Survival rates and body conditioning scores were compared after one year of treatment. RESULTS: CONCLUSION: These data support the hypothesis that various cancers may utilize a mechanism that is present in normal pregnancy that involves secretion of a progesterone-induced protein that blocks natural killer cell activity. The hypothesis that the cancer cells have the capacity to direct local progesterone production is supported by demonstrating the benefit of a progesterone receptor antagonist in tumors restricted to males.
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Authors | Jerome H Check, Ebony Dix, Carrie Wilson, Diane Check |
Journal | Anticancer research
(Anticancer Res)
Vol. 30
Issue 12
Pg. 4921-3
(Dec 2010)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 21187471
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Hormone Antagonists
- Receptors, Progesterone
- Mifepristone
- Progesterone
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Topics |
- Animals
- Antineoplastic Agents
(pharmacology)
- Female
- Hormone Antagonists
(pharmacology)
- Male
- Mice
- Mice, Inbred C57BL
- Mifepristone
(pharmacology)
- Pregnancy
- Progesterone
(biosynthesis)
- Prostatic Neoplasms
(drug therapy, metabolism)
- Receptors, Progesterone
(antagonists & inhibitors, metabolism)
- Testicular Neoplasms
(drug therapy, metabolism)
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