Isoforms of apolipoprotein C-I associated with individuals with coronary artery disease.

Abstract

Apolipoprotein C-I (apoC-I) is a 6.6kDa serum protein associated with high density lipoproteins (HDL) and triglyceride-rich lipoproteins. In this study, apoC-I was examined in high density lipoprotein subfractions from individuals with and without coronary artery disease (CAD). New isoforms of apoC-I, were detected in the cohort of individuals with CAD using mass spectrometry while the expected apoC-I isoforms were absent. In addition, the apoC-I mass spectra for the CAD cohort had satellite peaks indicative of the involvement of oxidative processes. Further analysis of the mass spectra of the CAD and non-CAD cohorts suggest that the origin of these new isoforms may be due to genetic mutations that could compromise the function of apoC-I.

• Authors: D'Vesharronne Moore, Catherine McNeal, Ronald Macfarlane
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 404 Issue 4 Pg. 1034-8 (Jan 28 2011) ISSN: 1090-2104 [Electronic] United States
• PMID: 21187063 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Elsevier Inc. All rights reserved.

Chemical References

• Apolipoprotein C-I
• Protein Isoforms

Topics

• Apolipoprotein C-I (blood, genetics, metabolism)
• Cohort Studies
• Coronary Artery Disease (blood, metabolism)
• Humans
• Oxidation-Reduction
• Protein Isoforms (blood, genetics, metabolism)
• Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization