Abstract | OBJECTIVES: METHODS: RESULTS: The DPβE69 residue regardless of zygosity, but particularly if present on non-*0201 alleles, was of primary importance for the development of CBD and BeS, while other negatively charged residues DPβDE55, 56 and DPβDE84, 85 incrementally increased, although not independently, the risk. The DPβE69 positive alleles with charge -7 or -9 were associated with both CBD and BeS. The polymorphic residues DPβE69, DPβDE55, 56 and DPβDE84, 85 were responsible for the -9 charge and the first two residues for the -7 charge. CONCLUSIONS: In the absence of DPβE69, DRβE71 is a risk factor for CBD and BeS. DPβE69 and DRβE71 are adjacent to other amino acids that are also negatively charged, suggesting that the positively charged Be²⁺ modifies the local environment of the epitopes in a way that promotes interactions between peptides and T cells and results in CBD. Finally, the protective effect of the DPB1*0201 positive haplotype may involve particular polymorphisms outside of the DPB1 gene.
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Authors | K D Rosenman, M Rossman, V Hertzberg, M J Reilly, C Rice, E Kanterakis, D Monos |
Journal | Occupational and environmental medicine
(Occup Environ Med)
Vol. 68
Issue 7
Pg. 487-93
(Jul 2011)
ISSN: 1470-7926 [Electronic] England |
PMID | 21186201
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S., Review)
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Chemical References |
- HLA-DP Antigens
- HLA-DP beta-Chains
- HLA-DPB1 antigen
- HLA-DR Antigens
- HLA-DRB1 Chains
- Beryllium
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Topics |
- Adult
- Aged
- Alleles
- Berylliosis
(genetics)
- Beryllium
(toxicity)
- Chronic Disease
- Female
- Genetic Predisposition to Disease
- HLA-DP Antigens
(genetics)
- HLA-DP beta-Chains
- HLA-DR Antigens
(genetics)
- HLA-DRB1 Chains
- Heterozygote
- Homozygote
- Humans
- Male
- Middle Aged
- Polymorphism, Genetic
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