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Protective effect of embelin against acetic acid induced ulcerative colitis in rats.

Abstract
The aim of the present study is to evaluate the effect of embelin isolated from Embelia ribes on acetic acid induced colitis in rats. Experimental animals received embelin (25 and 50 mg/kg, p.o.) and sulfasalazine (100mg/kg, p.o.) for five consecutive days before induction of colitis by intra-rectal acetic acid (3% v/v) administration and the treatment continued up to 7 days. The colonic mucosal injury was assessed by clinical, macroscopic, biochemical and histopathological examinations. Embelin treatment significantly decreased clinical activity score, gross lesion score, percent affected area and wet colon weight when compared to acetic acid induced controls. The treatment also reduced significantly the colonic myeloperoxidase activity, lipid peroxides and serum lactate dehydrogenase and significantly increased the reduced glutathione. The histopathological studies also confirmed the foregoing findings. The protective effect may be due to its antioxidant and anti-inflammatory activities.
AuthorsBoreddy Shivanandappa Thippeswamy, Sekar Mahendran, Mahantesh I Biradar, Pooja Raj, Kamya Srivastava, Shrishailappa Badami, Veeresh Prabhakar Veerapur
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 654 Issue 1 Pg. 100-5 (Mar 01 2011) ISSN: 1879-0712 [Electronic] Netherlands
PMID21185828 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2010 Elsevier B.V. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents
  • Antioxidants
  • Benzoquinones
  • Gastrointestinal Agents
  • Sulfasalazine
  • Acetic Acid
  • embelin
Topics
  • Acetic Acid (toxicity)
  • Animals
  • Anti-Inflammatory Agents (administration & dosage, isolation & purification, pharmacology)
  • Antioxidants (administration & dosage, isolation & purification, pharmacology)
  • Benzoquinones (administration & dosage, isolation & purification, pharmacology)
  • Colitis, Ulcerative (drug therapy, physiopathology)
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Embelia (chemistry)
  • Gastrointestinal Agents (administration & dosage, isolation & purification, pharmacology)
  • Intestinal Mucosa (drug effects, pathology)
  • Male
  • Rats
  • Rats, Wistar
  • Sulfasalazine (pharmacology)

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