Abstract | BACKGROUND: MATERIAL/METHODS: The study enrolled 270 Caucasian renal transplant recipients (166 males, 104 females). METHODS: Genotyping of the rs5498 ICAM1 and the rs1041163 and rs3170794 VCAM1 gene polymorphisms was performed using real-time PCR. RESULTS: The distribution of genotypes and alleles of the studied polymorphisms in patients with DGF and without DGF showed no statistically significant differences. The risk of acute rejection was significantly higher in patients with the rs5498 ICAM1 GG genotype than in carriers of the AG and AA genotypes (OR 3.01; 95% CI 1.51-6.00, p=0.003). CONCLUSIONS: These results suggest that ICAM1 and VCAM1 gene polymorphisms play a minor role in pathogenesis of DGF. The rs5498 ICAM1 gene polymorphism is associated with increased risk of acute rejection of kidney allografts.
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Authors | Karolina Kłoda, Leszek Domanski, Andrzej Pawlik, Mateusz Kurzawski, Krzysztof Safranow, Kazimierz Ciechanowski |
Journal | Annals of transplantation
(Ann Transplant)
2010 Oct-Dec
Vol. 15
Issue 4
Pg. 15-20
ISSN: 2329-0358 [Electronic] United States |
PMID | 21183871
(Publication Type: Journal Article)
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Chemical References |
- Vascular Cell Adhesion Molecule-1
- Intercellular Adhesion Molecule-1
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Topics |
- Acute Disease
- Adult
- Delayed Graft Function
(genetics)
- Female
- Genotype
- Graft Rejection
(genetics)
- Heterozygote
- Humans
- Intercellular Adhesion Molecule-1
(genetics)
- Kidney Transplantation
(immunology)
- Male
- Middle Aged
- Polymorphism, Genetic
- Risk Assessment
- Transplantation, Homologous
- Vascular Cell Adhesion Molecule-1
(genetics)
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