Autoimmune inner ear disease in children.

Abstract

OBJECTIVE:

To determine the response to treatment of pediatric patients diagnosed with autoimmune inner ear disease.

PATIENTS:

Seven children who presented with sensorineural hearing loss and were diagnosed with autoimmune inner ear disease.

INTERVENTION:

Diagnosis through blood testing. Treatment with steroids and/or cytotoxic medication.

MAIN OUTCOME MEASURES:

Improvement in pure-tone average and speech discrimination scores on audiometric testing.

RESULTS:

Six of the 7 children (85.7%) improved with treatment, and the remaining patient had no measurable progression of disease.

CONCLUSION:

Children with autoimmune inner ear disease seem to benefit from treatment with steroids and/or cytotoxic medication. Although such medications must be used with caution in the pediatric population, they should not be withheld simply because of young age.

• Authors: Natalie C Huang, Robert T Sataloff
• Journal: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology (Otol Neurotol) Vol. 32 Issue 2 Pg. 213-6 (Feb 2011) ISSN: 1537-4505 [Electronic] United States
• PMID: 21178803 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Antimetabolites, Antineoplastic
• Antineoplastic Agents
• Antineoplastic Agents, Alkylating
• HLA-DR4 Antigen
• Steroids
• Cyclophosphamide
• Prednisone
• Methotrexate

Topics

• Adolescent
• Anti-Inflammatory Agents (therapeutic use)
• Antimetabolites, Antineoplastic (therapeutic use)
• Antineoplastic Agents (therapeutic use)
• Antineoplastic Agents, Alkylating (therapeutic use)
• Auditory Threshold
• Autoimmune Diseases (immunology)
• Blotting, Western
• Bone Conduction
• Child
• Child, Preschool
• Cyclophosphamide (therapeutic use)
• Female
• HLA-DR4 Antigen (immunology)
• Hearing Loss, Sensorineural (immunology)
• Hematologic Tests
• Humans
• Labyrinth Diseases (immunology)
• Male
• Methotrexate (therapeutic use)
• Prednisone (therapeutic use)
• Retrospective Studies
• Speech Perception
• Steroids (therapeutic use)