Multifunctional hollow nanoparticles based on graft-diblock copolymers for doxorubicin delivery.

Abstract

This article reports a flexible hollow nanoparticles, self-assembling from poly(N-vinylimidazole-co-N-vinylpyrrolidone)-g-poly(d,l-lactide) graft copolymers and methoxyl/functionalized-PEG-PLA diblock copolymers, as an anticancer drug doxorubicin (Dox) carrier for cancer targeting, imaging, and cancer therapy. This multifunctional hollow nanoparticle exhibited a specific on-off switch drug release behavior, owning to the pH-sensitive structure of imidazole, to release Dox in acidic surroundings (intracellular endosomes) and to capsulate Dox in neutral surroundings (blood circulation or extracellular matrix). Imaging by SPECT/CT shows that nanoparticle conjugated with folic acids ensures a high intratumoral accumulation due to the folate-binding protein (FBP)-binding effect. In vivo tumor growth inhibition shows that nanoparticles exhibited excellent antitumor activity and a high rate of apoptosis in cancer cells. After 80-day treatment course of nanoparticles, it did not appreciably cause heart, liver and kidney damage by inactive Dox or polymeric materials. The results indicate that the flexible carriers with an on-off switched drug release may be allowed to accurately deliver to targeted tumors for cancer therapy.

• Authors: Pei-Lin Lu, Yi-Chun Chen, Ta-Wei Ou, Hung-Hao Chen, Hsieh-Chih Tsai, Chih-Jen Wen, Chun-Liang Lo, Shiaw-Pyng Wey, Kun-Ju Lin, Tzu-Chen Yen, Ging-Ho Hsiue
• Journal: Biomaterials (Biomaterials) Vol. 32 Issue 8 Pg. 2213-21 (Mar 2011) ISSN: 1878-5905 [Electronic] Netherlands
• PMID: 21176954 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Antibiotics, Antineoplastic
• Biocompatible Materials
• Polymers
• Doxorubicin

Topics

• Animals
• Antibiotics, Antineoplastic (administration & dosage, chemistry, therapeutic use)
• Biocompatible Materials (chemistry)
• Doxorubicin (administration & dosage, chemistry, therapeutic use)
• Drug Delivery Systems (methods)
• Female
• HeLa Cells
• Humans
• Materials Testing
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Molecular Structure
• Nanoparticles (chemistry)
• Neoplasms (drug therapy)
• Polymers (chemistry)
• Random Allocation
• Tissue Distribution