Clinical immunology review series: an approach to desensitization.

Abstract

Allergen immunotherapy describes the treatment of allergic disease through administration of gradually increasing doses of allergen. This form of immune tolerance induction is now safer, more reliably efficacious and better understood than when it was first formally described in 1911. In this paper the authors aim to summarize the current state of the art in immunotherapy in the treatment of inhalant, venom and drug allergies, with specific reference to its practice in the United Kingdom. A practical approach has been taken, with reference to current evidence and guidelines, including illustrative protocols and vaccine schedules. A number of novel approaches and techniques are likely to change considerably the way in which we select and treat allergy patients in the coming decade, and these advances are previewed.

• Authors: M T Krishna, A P Huissoon
• Journal: Clinical and experimental immunology (Clin Exp Immunol) Vol. 163 Issue 2 Pg. 131-46 (Feb 2011) ISSN: 1365-2249 [Electronic] England
• PMID: 21175592 (Publication Type: Journal Article, Review)
• Copyright: © 2010 The Authors. Clinical and Experimental Immunology © 2010 British Society for Immunology.

Chemical References

• Adjuvants, Immunologic
• Adrenergic beta-Antagonists
• Allergens
• Angiotensin-Converting Enzyme Inhibitors
• Anti-Allergic Agents
• Arthropod Venoms
• Histamine Antagonists

Topics

• Adjuvants, Immunologic (therapeutic use)
• Adrenergic beta-Antagonists (therapeutic use)
• Allergens (administration & dosage, therapeutic use)
• Angiotensin-Converting Enzyme Inhibitors (therapeutic use)
• Animals
• Anti-Allergic Agents (therapeutic use)
• Arthropod Venoms (administration & dosage, therapeutic use)
• Asthma (therapy)
• Contraindications
• Desensitization, Immunologic (methods)
• Female
• Histamine Antagonists (therapeutic use)
• Humans
• Hymenoptera (immunology)
• Hypersensitivity (therapy)
• Insect Bites and Stings (therapy)
• Pregnancy
• Rhinitis, Allergic, Perennial (therapy)
• United Kingdom