Change in thigh muscle cross-sectional area through administration of an anabolic steroid during routine stroke rehabilitation in hemiplegic patients.

Abstract

OBJECTIVE:

The aim of this study was to clarify the effect of administration of an anabolic steroid (AS) without the addition of specific training in stroke patients by measuring the cross-sectional area (CSA) of the thigh.

DESIGN:

Twenty-six hemiplegic stroke patients during subacute rehabilitation were randomly assigned to a metenolone enanthate (ME) administration group or a control group (CT group). In the ME group, ME (100 mg) was injected intramuscularly weekly for 6 wks in the ME group. The CSA of the bilateral thigh muscles was measured using computed tomography. Motor subscore of the Functional Independence Measure (FIM-M) was assessed before the experimental period.

RESULTS:

At the end of 6 wks, the CSA increase in the ME group (13.4%, affected side; 14.5%, unaffected side) was significantly larger than that in the CT group (3.3%, affected side; 5.2%, unaffected side). Correlation coefficients between the initial FIM-M score and the CSA increase at 6 wks were -0.754 for the affected side and -0.567 for the unaffected side in the ME group and 0.199 for the affected side and 0.431 for the unaffected side in the CT group.

CONCLUSIONS:

ME administration is effective for improving muscle CSA and, thus, muscle strengthening in stroke rehabilitation. The CSA increase in the ME group was most prominent in patients with a low initial FIM-M score.

• Authors: Sayaka Okamoto, Shigeru Sonoda, Genichi Tanino, Ken Tomida, Hideto Okazaki, Izumi Kondo
• Journal: American journal of physical medicine & rehabilitation (Am J Phys Med Rehabil) Vol. 90 Issue 2 Pg. 106-11 (Feb 2011) ISSN: 1537-7385 [Electronic] United States
• PMID: 21173687 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anabolic Agents
• Methenolone

Topics

• Aged
• Anabolic Agents (administration & dosage)
• Anatomy, Cross-Sectional
• Disability Evaluation
• Female
• Hemiplegia (rehabilitation)
• Humans
• Injections, Intramuscular
• Male
• Methenolone (administration & dosage)
• Muscle Strength (drug effects)
• Muscle, Skeletal (anatomy & histology, diagnostic imaging)
• Stroke Rehabilitation
• Thigh
• Tomography, X-Ray Computed