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FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor.

Abstract
FLP 62064 [N-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-3-amine] is a dual inhibitor of prostaglandin synthetase and 5-lipoxygenase. The compound had anti-inflammatory activity in vivo in a number of models. It inhibited peritoneal inflammation induced by immune-complex when given locally. When applied to the skin, FPL 62064 inhibited UV irradiation-induced erythema and PGE2 formation in the guinea pig and also oedema formation and eicosanoid production in the mouse ear produced by arachidonic acid. Co-injected with arachidonic acid in rabbit skin, FPL 62064 inhibited oedema and eicosanoid formation.
AuthorsA Blackham, R J Griffiths, C Hallam, J Mann, P D Mitchell, A A Norris, W T Simpson
JournalAgents and actions (Agents Actions) Vol. 30 Issue 3-4 Pg. 432-42 (Jun 1990) ISSN: 0065-4299 [Print] SWITZERLAND
PMID2117338 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antigen-Antibody Complex
  • Arachidonic Acids
  • Cyclooxygenase Inhibitors
  • Eicosanoids
  • Lipoxygenase Inhibitors
  • Pyrazoles
  • FPL 62064
  • Arachidonic Acid
  • Carrageenan
  • Arachidonate Lipoxygenases
  • Tetradecanoylphorbol Acetate
  • Prostaglandin D2
Topics
  • Administration, Cutaneous
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
  • Antigen-Antibody Complex
  • Arachidonate Lipoxygenases (antagonists & inhibitors)
  • Arachidonic Acid
  • Arachidonic Acids
  • Carrageenan
  • Cyclooxygenase Inhibitors
  • Eicosanoids (metabolism)
  • Female
  • Guinea Pigs
  • Humans
  • In Vitro Techniques
  • Inflammation (drug therapy, etiology)
  • Lipoxygenase Inhibitors
  • Mice
  • Neutrophils (enzymology)
  • Prostaglandin D2 (analysis)
  • Pyrazoles (pharmacology)
  • Rabbits
  • Tetradecanoylphorbol Acetate
  • Ultraviolet Rays

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