FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor.

FLP 62064 [N-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-3-amine] is a dual inhibitor of prostaglandin synthetase and 5-lipoxygenase. The compound had anti-inflammatory activity in vivo in a number of models. It inhibited peritoneal inflammation induced by immune-complex when given locally. When applied to the skin, FPL 62064 inhibited UV irradiation-induced erythema and PGE2 formation in the guinea pig and also oedema formation and eicosanoid production in the mouse ear produced by arachidonic acid. Co-injected with arachidonic acid in rabbit skin, FPL 62064 inhibited oedema and eicosanoid formation.
AuthorsA Blackham, R J Griffiths, C Hallam, J Mann, P D Mitchell, A A Norris, W T Simpson
JournalAgents and actions (Agents Actions) Vol. 30 Issue 3-4 Pg. 432-42 (Jun 1990) ISSN: 0065-4299 [Print] SWITZERLAND
PMID2117338 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antigen-Antibody Complex
  • Arachidonic Acids
  • Cyclooxygenase Inhibitors
  • Eicosanoids
  • Lipoxygenase Inhibitors
  • Pyrazoles
  • FPL 62064
  • Arachidonic Acid
  • Carrageenan
  • Arachidonate Lipoxygenases
  • Tetradecanoylphorbol Acetate
  • Prostaglandin D2
  • Administration, Cutaneous
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
  • Antigen-Antibody Complex
  • Arachidonate Lipoxygenases (antagonists & inhibitors)
  • Arachidonic Acid
  • Arachidonic Acids
  • Carrageenan
  • Cyclooxygenase Inhibitors
  • Eicosanoids (metabolism)
  • Female
  • Guinea Pigs
  • Humans
  • In Vitro Techniques
  • Inflammation (drug therapy, etiology)
  • Lipoxygenase Inhibitors
  • Mice
  • Neutrophils (enzymology)
  • Prostaglandin D2 (analysis)
  • Pyrazoles (pharmacology)
  • Rabbits
  • Tetradecanoylphorbol Acetate
  • Ultraviolet Rays

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: