[The effect of ischemic preconditioning on adenosine phosphate content after spinal cord ischemia in rabbits].

Abstract

AIM:

To study the effect of ischemic preconditioning (IP) on adenosine phosphate content after spinal cord ischemia in rabbits.

METHODS:

We established a lumbar spinal cord ischemia model by inflating the balloon of a 4F Swan-Ganz catheter positioned in the abdominal aorta of the rabbits. All rabbits were divided into sham-operated group, ischemic group and IP group. Adenosine phosphate content in spinal cord of all rabbits was determined at 4 hours, 2 days and 5 days after spinal cord ischemia by using reverse phase HPLC.

RESULTS:

ATP content in lumbar spinal cord of rabbits in ischemic group was markedly reduced (P < 0.01 vs sham-operated group). But in IP group, it was obviously elevated at each time point compared with ischemic group (P < 0.01).

CONCLUSION:

IP can significantly elevated ATP content in postischemic lumbar spinal cord in rabbits. This may be one of the mechanisms that IP can protect spinal cord from ischemic injury.

• Authors: G Meng, L B Zhu, Y F Yu, J Liao, Y L Zhao
• Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology (Zhongguo Ying Yong Sheng Li Xue Za Zhi) Vol. 17 Issue 2 Pg. 144-7 (May 2001) ISSN: 1000-6834 [Print] China
• PMID: 21171402 (Publication Type: English Abstract, Journal Article)

Chemical References

• Adenine Nucleotides

Topics

• Adenine Nucleotides (metabolism)
• Animals
• Disease Models, Animal
• Female
• Ischemic Preconditioning
• Male
• Rabbits
• Reperfusion
• Spinal Cord (metabolism)
• Spinal Cord Ischemia (metabolism)