Abstract | AIM: METHODS: Intestinal ischemia/reperfusion model in mice were set up and 32 mice of Kunming species were divided randomly into 4 groups (n=8): Sham group, I/R group, I/R + GLP-2 group and I/R + glutamine group. The morphologic changes of intestinal mucosa were observed under LM. The villus height and crypt depth of intestine, the activity of diamine oxidase (DAO) in intestine and bacterial translocation rates of mesenteric lymph nodes (MLN) were detected. RESULTS: Compared with sham operation group, the intestinal villi were sloughed in I/R group with decreased villus height and crypt depth (P < 0.01), the DAO activities were decreased (P < 0.01), and MLN bacterial translocation rates were increased (P < 0.05). While GLP-2 administration improved the villus damage, increased DAO activity (P < 0.01), and decreased MLN bacterial translocation rates (P < 0.05), compared with I/R group. CONCLUSION:
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Authors | Li-li Guan, De-zheng Gong, Nan Tian, Yuan Zou |
Journal | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
(Zhongguo Ying Yong Sheng Li Xue Za Zhi)
Vol. 21
Issue 2
Pg. 192-4
(May 2005)
ISSN: 1000-6834 [Print] China |
PMID | 21171341
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Disease Models, Animal
- Glucagon-Like Peptide 2
(pharmacology)
- Intestinal Mucosa
(drug effects, pathology, physiopathology)
- Intestine, Small
(blood supply)
- Male
- Mice
- Mice, Inbred Strains
- Reperfusion Injury
(pathology, physiopathology)
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