Abstract | OBJECTIVE: METHODS: Sixty-four BPH/LUTS patients with nocturia were equally randomized into two groups, one treated with doxazosin (4 mg/d), and the other with frusemide (40 mg/d) and doxazosin (4 mg/d), given 6 h before sleep, both for 4 weeks. Urine volume, IPSS, QOL, serum electrolytes, plasma osmolality were recorded and compared between the two groups before and after the treatment. RESULTS: Compared with the doxazosin group, the frusemide plus doxazosin group showed significantly reduced nocturia frequency (P < 0.01), increased daytime urine output (P < 0.01), decreased nocturia urine output (P < 0.01), unchanged total urine output (P > 0.05), improved IPSS and QOL (P < 0.05, P < 0.01), but with no remarkable differences in the levels of serum sodium, potassium, chlorine, and osmotic pressure (P > 0.05). CONCLUSION:
|
Authors | Shi-yong Huang, Shao-xing Zhu, Bang-wei Zeng, De-sheng Zhu, Rong-jin Fang |
Journal | Zhonghua nan ke xue = National journal of andrology
(Zhonghua Nan Ke Xue)
Vol. 16
Issue 9
Pg. 807-10
(Sep 2010)
ISSN: 1009-3591 [Print] China |
PMID | 21171265
(Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)
|
Chemical References |
|
Topics |
- Aged
- Aged, 80 and over
- Doxazosin
(therapeutic use)
- Furosemide
(therapeutic use)
- Humans
- Male
- Middle Aged
- Nocturia
(drug therapy, etiology)
- Prostatic Hyperplasia
(complications, drug therapy)
|