Abstract | BACKGROUND: MATERIAL/METHODS: RESULTS: Out of the 3 NRAMP1 polymorphisms, a trend of increased incidence of INT4 polymorphism was found in the patients' group compared to the control group. A lack of association was observed between the 2 groups as far as the other 2 polymorphisms (D543N, 3'UTR) are concerned. INT4-CC homozygotes were found to have a higher risk to develop pulmonary tuberculosis compared to GG homozygotes (p=0.022). An increased incidence G/ TGTG/C genotype combination was found in the patients' group as compared to controls. G/ TGTG/C genotype combination was associated with a 36% higher risk of developing pulmonary tuberculosis (p=0.004) compared to the baseline expression of G/ TGTG/G combination. CONCLUSIONS:
|
Authors | Marios K Stagas, Georgios S Papaetis, Dora Orphanidou, Charalambos Kostopoulos, Stavroula Syriou, Martin Reczko, Nikolaos Drakoulis |
Journal | Medical science monitor : international medical journal of experimental and clinical research
(Med Sci Monit)
Vol. 17
Issue 1
Pg. PH1-6
(Jan 2011)
ISSN: 1643-3750 [Electronic] United States |
PMID | 21169917
(Publication Type: Journal Article)
|
Chemical References |
- Cation Transport Proteins
- DNA Primers
- natural resistance-associated macrophage protein 1
|
Topics |
- Adult
- Aged
- Case-Control Studies
- Cation Transport Proteins
(genetics)
- DNA Primers
(genetics)
- Female
- Genetic Predisposition to Disease
(genetics)
- Genotype
- Greece
(epidemiology)
- Humans
- Incidence
- Male
- Middle Aged
- Polymorphism, Genetic
(genetics)
- Tuberculosis
(epidemiology, ethnology, genetics)
|