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Evaluation of the bioactivity of novel spiroisoxazoline typecompounds against normal and cancer cell lines.

Abstract
The aim of this study was to investigate the in vitro cellular activity of novel spiroisoxazoline type compounds against normal and cancer cell lines from lung tissue (Hs888Lu), neuron-phenotypic cells (SH-SY5Y), neuroblastoma (SH-SY5Y), human histiocytic lymphoma (U937), lung cancer (A549), and leukaemia (HL-60). Our bioassay program revealed that the spiroisoxazoline type compounds show cytotoxicity only in lymphoma cell lines, which is in contrast with the pyrrolidine precursor of these spiroisoxazoline compounds, where significant cytotoxicity is seen in all normal and cancer cell lines. These data suggest a tumour-specific mechanism of action. In addition these data also show that spiroisoxazoline compounds are non-toxic in the human neuronphenotypic neuroblastoma SH-SY5Y cell line, and furthermore that they might protect cells from neurodegenerative disease.
AuthorsNigar Najim, Yaser Bathich, Mazatulikhma Mat Zain, Ahmad Sazali Hamzah, Zurina Shaameri
JournalMolecules (Basel, Switzerland) (Molecules) Vol. 15 Issue 12 Pg. 9340-53 (Dec 17 2010) ISSN: 1420-3049 [Electronic] Switzerland
PMID21169884 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Cytotoxins
  • Pyrrolidines
Topics
  • Antineoplastic Agents (chemistry, pharmacology)
  • Biological Assay (methods)
  • Cytotoxins (chemistry, pharmacology)
  • Drug Screening Assays, Antitumor
  • HL-60 Cells
  • Humans
  • Neoplasms (drug therapy)
  • Neurodegenerative Diseases (drug therapy)
  • Pyrrolidines (chemistry, pharmacology)
  • U937 Cells

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