Abstract | BACKGROUND: METHODS: From January 2009 to July 2010, we transplanted 52 pancreas grafts, including, 50 simultaneous pancreas- kidney transplantations (SPK), 1 after a kidney graft, and 1 alone. For 3 SPK donors the P-PASS was not available. All transplantations were performed using systemic venous and enteric drainage. The immunosuppression protocol included antibody induction with antithymocyte globulin and maintenance therapy with steroids, tacrolimus, and mycophenolate mofetil. The peak CRP in the first 3 postoperative days was used as a marker for IRI. RESULTS: The mean P-PASS of our donors was 16.4 ± 2.6 (range, 12-22). We compared 24 patients receiving organs from "ideal" donors (P-PASS <17; ID) with 25 receiving grafts from extended-criteria donors (P-PASS ≥17; ED). There was no significant difference in the incidence of graft loss among ID versus ED grafts (20.8% vs 20.0%; P = 1.0). Comparing the rates of postoperative complications of patients, we did not observe a significant difference in graft thrombosis (4.2% vs 16.0%; P = .349), relaparotomy (29.2% vs 40.0%; P = .551), a pancreatic fistula (37.5% vs 28.0%; P = .543), or the length of hospital stay (36.5 ± 19.2 vs 37.4 ± 20.8 days; P = .875), respectively. Regarding IRI, there was no significant difference in peak CRP values (14.1 ± 5.5 vs 16.2 ± 6.0 mg/dL; P = .211). CONCLUSION: This single center analysis failed to show that P-PASS significantly predicted pancreas graft survival, postoperative morbidity, or IRI severity. These findings suggested a chance to increase the donor pool using extended-criteria donors.
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Authors | G Woeste, C Moench, I A Hauser, H Geiger, E Scheuermann, W O Bechstein |
Journal | Transplantation proceedings
(Transplant Proc)
Vol. 42
Issue 10
Pg. 4202-5
(Dec 2010)
ISSN: 1873-2623 [Electronic] United States |
PMID | 21168664
(Publication Type: Journal Article)
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Copyright | Copyright © 2010 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- C-Reactive Protein
(analysis)
- Graft Survival
- Humans
- Pancreas Transplantation
(adverse effects)
- Postoperative Complications
- Reperfusion Injury
- Tissue and Organ Procurement
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