Living-donor liver transplantation in 126 patients with biliary atresia: single-center experience.

Abstract

OBJECTIVES:

To describe our experience with 126 consecutive living-donor liver transplantation (LDLT) procedures performed because of biliary atresia and to evaluate the optimal timing of the operation.

PATIENTS AND METHODS:

Between May 2001 and January 2010,126 patients with biliary atresia underwent 130 LDLT procedures. Mean (SD) patient age was 3.3 (4.2) years, and body weight was 13.8 (10.7) kg. Donors included 64 fathers, 63 mothers, and 3 other individuals. The left lateral segment was the most commonly used graft (75%). Patients were divided into 3 groups according to body weight: group 1, less than 8 kg (n = 40); group 2,8 to 20 kg (n = 63); and group 3, more than 20 kg (n = 23). Medical records were reviewed retrospectively. Follow up was 4.5 (2.7) years.

RESULTS:

All group 3 donors underwent left lobectomy, and all group 1 donors underwent left lateral segmentectomy. No donors required a second operation or died. Comparison of the 3 groups demonstrated that recipient Pediatric End-Stage Liver Disease score in group 1 was highest, operative blood loss in group 2 was lowest (78 mL/kg), and operative time in group 3 was longest (1201 minutes). Hepatic artery complications occurred more frequently in group 1 (17.9%), and biliary stenosis (43.5%) and gastrointestinal perforation (8.7%) occurred more frequently in group 3. The overall patient survival rates at 1, 5, and 9 years was 98%, 97%, and 97%, respectively. Five-year patient survival rate in groups 1,2, and 3 were 92.5%, 100%, and 95.7%, respectively. Gastrointestinal perforation (n = 2) was the primary cause of death.

CONCLUSIONS:

Living-donor liver transplantation is an effective treatment of biliary atresia, with good long-term outcome. It seems that the most suitable time to perform LDLT to treat biliary atresia is when the patient weighs 8 to 20 kg.

• Authors: K Mizuta, Y Sanada, T Wakiya, T Urahashi, M Umehara, S Egami, S Hishikawa, N Okada, Y Kawano, T Saito, M Hayashida, S Takahashi, H Yoshino, A Shimizu, Y Takatsuka, T Kitamura, Y Kita, T Uno, Y Yoshida, M Hyodo, Y Sakuma, T Fujiwara, K Ushijima, K Sugimoto, M Ohmori, S Ohtomo, K Sakamoto, M Nakata, T Yano, H Yamamoto, E Kobayashi, Y Yasuda, H Kawarasaki
• Journal: Transplantation proceedings (Transplant Proc) Vol. 42 Issue 10 Pg. 4127-31 (Dec 2010) ISSN: 1873-2623 [Electronic] United States
• PMID: 21168643 (Publication Type: Journal Article)
• Copyright: Copyright © 2010 Elsevier Inc. All rights reserved.

Chemical References

• Immunosuppressive Agents

Topics

• Adult
• Biliary Atresia (surgery)
• Female
• Humans
• Immunosuppressive Agents (administration & dosage)
• Liver Transplantation
• Living Donors
• Male
• Middle Aged