A microbiological study of failed penicillin therapy for gonococcal urethritis in Durban.

Abstract

Seventy-five men presenting with persistent urethral discharge after penicillin therapy were investigated for sexually transmitted pathogens during July - September 1987. The major aetiological agent isolated was Neisseria gonorrhoeae (58 patients (77.3%]. Penicillinase-producing N. gonorrhoeae (PPNG) accounted for 58.6% of 58 isolates. Chlamydia trachomatis was detected in 10.7% of patients and Trichomonas vaginalis in 14.7% of patients. When there is a high prevalence of PPNG, the use of penicillin as a first-line agent for therapy should be discontinued in favour of an agent active against PPNG and non-PPNG strains. Furthermore, in view of the relatively high prevalence of T. vaginalis, patients returning with persistent urethral discharge should be investigated and treated for infection with this protozoan.

• Authors: A A Hoosen, K D Coetzee, J van den Ende
• Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde (S Afr Med J) Vol. 78 Issue 4 Pg. 189-91 (Aug 18 1990) ISSN: 0256-9574 [Print] South Africa
• PMID: 2116671 (Publication Type: Journal Article)

Chemical References

• Penicillin G Procaine
• Penicillin G

Topics

• Adolescent
• Adult
• Animals
• Chlamydia trachomatis (isolation & purification)
• Drug Resistance, Microbial
• Gonorrhea (drug therapy, microbiology)
• Humans
• Male
• Middle Aged
• Neisseria gonorrhoeae (isolation & purification)
• Penicillin G (therapeutic use)
• Penicillin G Procaine (therapeutic use)
• Recurrence
• Trichomonas vaginalis (isolation & purification)
• Urethritis (drug therapy, microbiology)