Abstract |
The therapeutic efficacy of single intramuscular doses of ceftriaxone ( Rocephin; Roche) (62.5, 125 and 250 mg), administered without probenecid, was evaluated in 167 adult males with uncomplicated acute gonococcal urethritis. Cure rates of 100% were achieved at 62.5 mg and 250 mg. In the 125 mg dose group, Neisseria gonorrhoeae was isolated from 1 patient at follow-up after therapy. Reinfection was suspected, since this patient returned on day 10 and admitted to sexual contact 2 days previously. Side-effects were minimal, and patient acceptance was better for ceftriaxone dissolved in lignocaine than in sterile water. Chlamydia trachomatis was detected at follow-up in 14.4% patients, confirming that ceftriaxone has no significant effect on chlamydial infection and additional treatment is necessary for patients with coexistent infection.
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Authors | A A Hoosen, N O'Farrell, K D Coetzee, J van den Ende |
Journal | South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
(S Afr Med J)
Vol. 78
Issue 4
Pg. 187-9
(Aug 18 1990)
ISSN: 0256-9574 [Print] South Africa |
PMID | 2116670
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Acute Disease
- Adolescent
- Adult
- Ceftriaxone
(administration & dosage)
- Chlamydia trachomatis
(isolation & purification)
- Evaluation Studies as Topic
- Gonorrhea
(drug therapy)
- Humans
- Injections, Intramuscular
- Male
- Neisseria gonorrhoeae
(isolation & purification)
- Ureaplasma
(isolation & purification)
- Urethritis
(drug therapy)
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