Abstract | BACKGROUND:
Type 2 diabetes mellitus (T2DM) has become an epidemic health problem worldwide. Compared to Western countries, in Asia, T2DM occurs in patients with a lower body mass index (BMI) due to central obesity and decreased pancreatic β-cell function. The efficacy of laparoscopic mini- gastric bypass (LMGB) in obese patients with T2DM has been proven by numerous studies. Treatment outcomes of LMGB for non-obese T2DM patients are also estimated to be excellent. The aim of the present pilot study was to evaluate the efficacy and safety of LMBG in non-obese T2DM patients (BMI 25-30 kg/m(2)). METHODS: Ten consecutive patients underwent LMGB at our hospital from August 2009 to October 2009. Preoperative data including glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG), and 2 h postprandial glucose (2-h PPG) were compared with data collected at 1, 3, and 6 postoperative months. RESULTS: All procedures were completed laparoscopically. Mean age of the patients was 46.9 years, mean BMI was 27.2 kg/m(2), mean operative time was 150.5 min, and mean postoperative hospital stay was 5.3 days. Neither mortality nor major complications occurred. Mean preoperative glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG), 2-h PPG, and C-peptide level were 9.7%, 222 mg/dl, 343 mg/dl, and 2.78 ng/ml, respectively. At the sixth postoperative month, HbA1c, FPG, 2-h PPG, and C-peptide level measured 6.7%, 144 mg/dl, 203 mg/dl, and 2.18 ng/ml. CONCLUSIONS: This preliminary study demonstrated the resolution of hyperglycemia in 70% of non-obese T2DM patients (BMI 25-30 kg/m(2)). Although long-term follow-up data are required, early operative outcomes were satisfactory in terms of glycemic control and safety of the procedure.
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Authors | Zisun Kim, Kyung Yul Hur |
Journal | World journal of surgery
(World J Surg)
Vol. 35
Issue 3
Pg. 631-6
(Mar 2011)
ISSN: 1432-2323 [Electronic] United States |
PMID | 21165621
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Adult
- Blood Glucose
(analysis)
- Body Mass Index
- Diabetes Mellitus, Type 2
(diagnosis, surgery)
- Female
- Follow-Up Studies
- Gastric Bypass
(methods)
- Humans
- Korea
- Laparoscopy
(adverse effects, methods)
- Male
- Middle Aged
- Minimally Invasive Surgical Procedures
(adverse effects, methods)
- Pilot Projects
- Postoperative Care
- Preoperative Care
- Risk Assessment
- Sampling Studies
- Time Factors
- Treatment Outcome
- Weight Loss
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