Efficiency of lyticase (bacterial enzyme) in experimental candidal vaginitis in mice.

Abstract

Lyticase (a bacterial enzyme) was tested as a new antimycotic drug. Of all objects studied, Cellulomonas cellulans AC-870 strain proved to be most productive for this enzyme. A technology for lyticase isolation and purification was proposed. An experimental model of recurrent vaginal candidiasis was created. The model includes combined antibiotic and estradiol therapy. Antimycotic effect of lyticase on the model of recurrent vaginal candidiasis in mice was demonstrated.

• Authors: N P Sachivkina, E G Kravtsov, E A Wasileva, I V Anokchina, M V Dalin
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 149 Issue 6 Pg. 727-30 (Nov 2010) ISSN: 1573-8221 [Electronic] United States
• PMID: 21165431 (Publication Type: Journal Article)

Chemical References

• Multienzyme Complexes
• lyticase
• Glucan Endo-1,3-beta-D-Glucosidase
• Peptide Hydrolases

Topics

• Animals
• Candidiasis, Vulvovaginal (drug therapy)
• Female
• Glucan Endo-1,3-beta-D-Glucosidase (metabolism, therapeutic use)
• Mice
• Multienzyme Complexes (metabolism, therapeutic use)
• Peptide Hydrolases (metabolism, therapeutic use)