Penicillamine-induced Elastosis Perforans Serpiginosa and Cutis Laxa in a Patient with Wilson's Disease.

Abstract

Elastosis perforans serpiginosa (EPS) is a rare reactive perforating dermatosis that is characterized by the transepidermal elimination of abnormal elastic fibers. Penicillamine, which is one of the clear triggers for EPS, is a heavy metal chelator that is primarily used for disorders such as cystinuria and Wilson's disease. It may cause alterations in the dermal elastic tissue such as pseudo-pseudoxanthoma elasticum, acquired cutis laxa, EPS and anetoderma. Herein we present a case of cutis laxa and EPS in a 34-year-old man who was previously on a long-term, high-dose of penicillamine for Wilson's disease. The combination of EPS and cutis laxa induced by penicillamine has rarely been reported and we report the first such case in Korea.

• Authors: Se Young Na, Mira Choi, Min Ji Kim, Jong Hee Lee, Soyun Cho
• Journal: Annals of dermatology (Ann Dermatol) Vol. 22 Issue 4 Pg. 468-71 (Nov 2010) ISSN: 2005-3894 [Electronic] Korea (South)
• PMID: 21165224 (Publication Type: Case Reports)