Abstract | BACKGROUND: OBJECTIVE: The aim of this study was to determine the chemokine receptor CCR3 expression pattern and the protein expression level in selected malignant cutaneous tumors. METHODS: RESULTS: Western blot analysis showed that CCR3 protein was more expressed in the MM cell lines (G361, SK-MEL-2,SK-MEL-24) than that in the SCC cell line (A431), and the immunohistochemical analysis showed that CCR3 protein was overexpressed in MM and SCC, it was mildly expressed in BCC and it was hardly expressed in normal tissue. CONCLUSION: This study demonstrated via immunochemistry that CCR3 was more expressed in MM, followed by SCC and BCC. The existence of CCR3 protein may enhance the tumorigenic potential of malignant cutaneous tumors.
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Authors | Yoon-Jin Lee, Dae-Hyun Kim, Sang-Han Lee, Hae-Seon Nam, Mi Ryung Roh, Moon-Kyun Cho |
Journal | Annals of dermatology
(Ann Dermatol)
Vol. 22
Issue 4
Pg. 412-7
(Nov 2010)
ISSN: 2005-3894 [Electronic] Korea (South) |
PMID | 21165210
(Publication Type: Journal Article)
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