Urothelial damage and tumor initiation by urinary metabolites of sodium o-phenylphenate in the urinary bladder of female rats.

Abstract

Intravesical instillation of 2-phenyl-1,4-benzoquinone (PBQ), a metabolite of sodium o-phenylphenate (Na-OPP), at a concentration of 0.1% in saline caused acute epithelial injury, prolonged inflammation and epithelial hyperplasia in female F344 rats. Ten such instillations of PBQ within 5 weeks resulted in the development of preneoplastic lesions of the urinary bladder epithelium when followed by 5% sodium saccharin feeding for 31 weeks. Since neither urothelial damage nor tumor-initiating activity was observed with either Na-OPP itself or another metabolite, phenylhydroquinone, PBQ may play an essential role in Na-OPP urinary bladder carcinogenesis.

• Authors: R Hasegawa, F Furukawa, K Toyoda, H Sato, M Takahashi, Y Hayashi
• Journal: Japanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 81 Issue 5 Pg. 483-8 (May 1990) ISSN: 0910-5050 [Print] Japan
• PMID: 2116397 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biphenyl Compounds
• 2-phenylphenol

Topics

• Administration, Intravesical
• Animals
• Biphenyl Compounds (toxicity)
• Female
• Hyperplasia (chemically induced)
• Rats
• Rats, Inbred F344
• Urinary Bladder (drug effects, pathology)
• Urinary Bladder Neoplasms (chemically induced, pathology)