Abstract | BACKGROUND: METHODS:
Pulmonary regurgitation was created by percutaneous cylindrical stent insertion in native pulmonary annulus of 8 sheep. One month after the initial procedure, the sheep with previous cylindrical stent implanted underwent the same implantation procedure of pulmonary valve stent. The valve stent consisted of a cup-shaped stent and pericardial valves. Hemodynamic assessments of the bioprosthetic pulmonary valve were obtained by echocardiography at immediately post-implant and at 2 months follow up. RESULTS: Successful transcatheter cylindrical stent insertion was performed in 7 sheep but failed in 1 sheep because the cylindrical stent was released to right ventricle outflow tract. After one month the 7 sheep with pulmonary regurgitation underwent valve stent implantation successfully. Echocardiography confirmed the stents were in desired position during the follow-up. No evidence of pulmonary valve insufficiency occurred in any animals. Echocardiography showed all heart function markers were normal. CONCLUSIONS: Percutaneous cylindrical stent insertion to induce significant pulmonary regurgitation in sheep was feasible, simple and reproducible. Percutaneous pulmonary valve stent implantation can reduce pulmonary regurgitation in a sheep model. Further development of animal model and clinical trials are warranted.
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Authors | Yuan Bai, Gang-Jun Zong, Hai-Bing Jiang, Wei-Ping Li, Hong Wu, Xian-Xian Zhao, Yong-Wen Qin |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 123
Issue 21
Pg. 3127-31
(Nov 2010)
ISSN: 2542-5641 [Electronic] China |
PMID | 21162968
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Animals
- Feasibility Studies
- Female
- Heart Valve Prosthesis
- Heart Valve Prosthesis Implantation
- Male
- Pulmonary Valve Insufficiency
(surgery)
- Sheep
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