Abstract | OBJECTIVE: METHODS: A case-control study was conducted on 49 women with endometriosis who underwent laparoscopy, 28 of whom had CPP and 21 without CPP. Samples from peritoneum of the rectouterine excavation (2 cm2) were obtained by laparoscopy, fixed in 4% formaldehyde, and underwent immunohistochemistry analysis using rabbit anti-TRPV1 (1:400) polyclonal antibody. RESULTS: Image analysis revealed that the immunoreactivity for TRPV1 was more frequent in specimens ( endometriosis foci) from women with CPP (n = 15 of 28, 53.6%), compared to samples from the endometriosis foci of women without CPP (n = 6 of 21, 28.6%; P = .04). There was no correlation with duration, intensity of pain, or stage of the disease ( endometriosis). DISCUSSION: The present study shows that TRPV1 expression in peritoneal endometriosis foci is related to CPP in women. However, this association is not related to the endometriosis stage. In view of the immunoreactivity for TRPV1 observed here, we believe that some endometriotic lesions may provide a scenario for TRPV1 to be tonically active and this activity may contribute to the underlying pathology of CPP.
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Authors | Marcelo Gondim Rocha, Júlio César Rosa e Silva, Alfredo Ribeiro da Silva, Francisco José Candido Dos Reis, Antonio Alberto Nogueira, Omero Benedicto Poli-Neto |
Journal | Reproductive sciences (Thousand Oaks, Calif.)
(Reprod Sci)
Vol. 18
Issue 6
Pg. 511-5
(Jun 2011)
ISSN: 1933-7205 [Electronic] United States |
PMID | 21160085
(Publication Type: Journal Article)
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Chemical References |
- TRPV Cation Channels
- TRPV1 protein, human
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Topics |
- Adult
- Case-Control Studies
- Chronic Disease
- Endometriosis
(metabolism, pathology)
- Female
- Humans
- Laparoscopy
- Pelvic Pain
(diagnosis, metabolism, pathology)
- Peritoneum
(metabolism)
- Severity of Illness Index
- TRPV Cation Channels
(metabolism)
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