Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.

Abstract

4-Hydroxycordoin (1), a natural isopentenyloxychalcone, is a plant secondary metabolite that is relatively rare. Since there are very few reports about the biological activities of 1, its potential benefits for periodontal disease were investigated. A marked and dose-dependent antibacterial activity of 1 was observed against the three major periodontal pathogens, Porphyromonas gingivalis, Fusobacterium nucleatum, and Prevotella intermedia. Moreover, compound 1 showed an antiadhesion effect, since it inhibited attachment of P. gingivalis to oral epithelial cells. Finally, using a macrophage model, the ability of 1 to inhibit the secretion of inflammatory mediators induced by Aggregatibacter actinomycetemcomitans lipopolysaccharide was demonstrated. The anti-inflammatory effect observed was associated with reduced activation of the nuclear factor-κB (NF-κB) p65 and activator protein-1 (AP-1) pathways.

• Authors: Mark Feldman, Shinichi Tanabe, Francesco Epifano, Salvatore Genovese, Massimo Curini, Daniel Grenier
• Journal: Journal of natural products (J Nat Prod) Vol. 74 Issue 1 Pg. 26-31 (Jan 28 2011) ISSN: 1520-6025 [Electronic] United States
• PMID: 21158427 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 4-hydroxycordoin
• Anti-Bacterial Agents
• Anti-Inflammatory Agents
• Chalcones
• Lipopolysaccharides
• Transcription Factor RelA
• Replication Protein C
• Dinoprostone

Topics

• Anti-Bacterial Agents (chemistry, isolation & purification, pharmacology)
• Anti-Inflammatory Agents (chemistry, isolation & purification, pharmacology)
• Chalcones (chemistry, isolation & purification, pharmacology)
• Dinoprostone (analysis, metabolism)
• Dose-Response Relationship, Drug
• Fabaceae (chemistry)
• Humans
• Lipopolysaccharides (pharmacology)
• Macrophages (drug effects)
• Models, Biological
• Molecular Structure
• Periodontal Diseases (drug therapy, microbiology)
• Replication Protein C (drug effects)
• Transcription Factor RelA (drug effects)