Efficacy of bimatoprost 0.03% in reducing intraocular pressure in patients with 360° synechial angle-closure glaucoma: a preliminary study.

Abstract

CONTEXT:

Peripheral anterior synechiae (PAS; synechiae anterior to functional trabecular meshwork) formation in primary angle-closure glaucoma (PACG) hampers access to uveoscleral outflow. Thus, the role of bimatoprost in such patients with 360° synechiae was evaluated.

AIMS:

To assess efficacy and safety profile of bimatoprost 0.03% in lowering intraocular pressure (IOP) in 360° synechial angle-closure glaucoma patients.

SETTINGS AND DESIGN:

This was a prospective, non-randomized, non-comparative, selective analysis, single-center pilot study.

MATERIALS AND METHODS:

A total of 23 eyes of 20 Indian chronic angle-closure glaucoma (CACG) patients with IOP greater than 21 mmHg, 360° PAS and no visual potential in the study eye underwent detailed eye examination. Baseline IOP was measured and YAG peripheral iridotomy was performed for complete angle-closure reconfirmation. Bimatoprost 0.03% was administered for 8 weeks as once-daily evening dose. IOP reduction within treatment group was determined with "paired t-test."

RESULTS:

The mean reduction in IOP from baseline to 8 weeks of bimatoprost therapy was 15.3 ± 9.5 mmHg (P < 0.001). The most commonly observed adverse event was conjunctival hyperemia (35%). Bimatoprost was well tolerated in the study.

CONCLUSIONS:

In this study, exclusively involving patients with 360° synechial angle-closure glaucoma and no visual potential, bimatoprost 0.03% treatment demonstrated a statistically significant IOP reduction. Hence, it can be inferred that bimatoprost 0.03% is an efficacious treatment modality in this subgroup of patients for reducing IOP.

• Authors: Prateep Vyas, Uday Naik, Jayasheel B Gangaiah
• Journal: Indian journal of ophthalmology (Indian J Ophthalmol) 2011 Jan-Feb Vol. 59 Issue 1 Pg. 13-6 ISSN: 1998-3689 [Electronic] India
• PMID: 21157066 (Publication Type: Journal Article)

Chemical References

• Amides
• Antihypertensive Agents
• Cloprostenol
• Bimatoprost

Topics

• Adult
• Aged
• Amides (administration & dosage, adverse effects)
• Antihypertensive Agents (administration & dosage, adverse effects)
• Bimatoprost
• Cloprostenol (administration & dosage, adverse effects, analogs & derivatives)
• Conjunctiva (blood supply)
• Drug Administration Schedule
• Female
• Glaucoma, Angle-Closure (drug therapy, physiopathology)
• Humans
• Hyperemia (chemically induced)
• Intraocular Pressure (drug effects)
• Male
• Middle Aged
• Pilot Projects
• Prospective Studies
• Treatment Outcome