Fibrinogen and D-dimer analysis of chronic subdural hematomas and computed tomography findings: a prospective study.

Abstract

OBJECTIVE:

We investigated the relationship between fibrinolytic factors and computed tomography (CT) findings in patients with chronic subdural hematomas (CSDHs).

METHODS:

Thirty-one patients with CSDHs were divided on the basis of CT findings into heterogeneous and homogeneous groups. A sample from the subdural hematoma was obtained at surgery to measure the concentrations of fibrinogen and D-dimer.

RESULTS:

The mean level of fibrinogen in the heterogeneous group, including the layering (n=4) and mixed (n=10) type, was 88.2±121.2 mg/dL, whereas in the homogeneous group, including high density (n=2), isodensity (n=9), and low density (n=6) types, it was <25 mg/dL. The concentration of fibrinogen was significantly higher in the heterogeneous group than in the homogeneous group (p=0.006). The mean level of D-dimer in the heterogeneous group was 35,407.9±16,325.5 μg/L, whereas for the homogeneous group it was 1476.4±2091.4 μg/L. The concentration of D-dimer was significantly higher in the heterogeneous group than in the homogeneous group (p<0.001).

CONCLUSIONS:

The layering and mixed types of CSDH exhibited higher concentrations of fibrinogen and D-dimer in subdural hematoma than the homogeneous types. These fibrinolytic factors appear to be associated with evolution in CSDHs with heterogeneous density.

• Authors: Seong-Hyun Park, Dong-Hun Kang, Jaechan Park, Jeong-Hyun Hwang, Sung-Kyoo Hwang, Joo-Kyung Sung, In-Suk Hamm
• Journal: Clinical neurology and neurosurgery (Clin Neurol Neurosurg) Vol. 113 Issue 4 Pg. 272-6 (May 2011) ISSN: 1872-6968 [Electronic] Netherlands
• PMID: 21156338 (Publication Type: Journal Article)
• Copyright: Copyright © 2010 Elsevier B.V. All rights reserved.

Chemical References

• Adrenal Cortex Hormones
• Anti-Inflammatory Agents
• Antifibrinolytic Agents
• Fibrin Fibrinogen Degradation Products
• fibrin fragment D
• Fibrinogen

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Adult
• Aged
• Aged, 80 and over
• Anti-Inflammatory Agents (therapeutic use)
• Antifibrinolytic Agents (therapeutic use)
• Brain (diagnostic imaging)
• Drainage
• Female
• Fibrin Fibrinogen Degradation Products (analysis, physiology)
• Fibrinogen (analysis, physiology)
• Hematoma, Subdural, Chronic (blood, diagnostic imaging)
• Humans
• Male
• Middle Aged
• Neurosurgical Procedures
• Prospective Studies
• Therapeutic Irrigation
• Tomography, X-Ray Computed