Abstract | OBJECTIVE: We investigated the relationship between fibrinolytic factors and computed tomography (CT) findings in patients with chronic subdural hematomas (CSDHs). METHODS: Thirty-one patients with CSDHs were divided on the basis of CT findings into heterogeneous and homogeneous groups. A sample from the subdural hematoma was obtained at surgery to measure the concentrations of fibrinogen and D-dimer. RESULTS: The mean level of fibrinogen in the heterogeneous group, including the layering (n=4) and mixed (n=10) type, was 88.2±121.2 mg/dL, whereas in the homogeneous group, including high density (n=2), isodensity (n=9), and low density (n=6) types, it was <25 mg/dL. The concentration of fibrinogen was significantly higher in the heterogeneous group than in the homogeneous group (p=0.006). The mean level of D-dimer in the heterogeneous group was 35,407.9±16,325.5 μg/L, whereas for the homogeneous group it was 1476.4±2091.4 μg/L. The concentration of D-dimer was significantly higher in the heterogeneous group than in the homogeneous group (p<0.001). CONCLUSIONS: The layering and mixed types of CSDH exhibited higher concentrations of fibrinogen and D-dimer in subdural hematoma than the homogeneous types. These fibrinolytic factors appear to be associated with evolution in CSDHs with heterogeneous density.
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Authors | Seong-Hyun Park, Dong-Hun Kang, Jaechan Park, Jeong-Hyun Hwang, Sung-Kyoo Hwang, Joo-Kyung Sung, In-Suk Hamm |
Journal | Clinical neurology and neurosurgery
(Clin Neurol Neurosurg)
Vol. 113
Issue 4
Pg. 272-6
(May 2011)
ISSN: 1872-6968 [Electronic] Netherlands |
PMID | 21156338
(Publication Type: Journal Article)
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Copyright | Copyright © 2010 Elsevier B.V. All rights reserved. |
Chemical References |
- Adrenal Cortex Hormones
- Anti-Inflammatory Agents
- Antifibrinolytic Agents
- Fibrin Fibrinogen Degradation Products
- fibrin fragment D
- Fibrinogen
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Topics |
- Adrenal Cortex Hormones
(therapeutic use)
- Adult
- Aged
- Aged, 80 and over
- Anti-Inflammatory Agents
(therapeutic use)
- Antifibrinolytic Agents
(therapeutic use)
- Brain
(diagnostic imaging)
- Drainage
- Female
- Fibrin Fibrinogen Degradation Products
(analysis, physiology)
- Fibrinogen
(analysis, physiology)
- Hematoma, Subdural, Chronic
(blood, diagnostic imaging)
- Humans
- Male
- Middle Aged
- Neurosurgical Procedures
- Prospective Studies
- Therapeutic Irrigation
- Tomography, X-Ray Computed
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